What is a common side effect of long-term prednisone use?

Long-term prednisone use is known to lead to several common side effects. One of the hallmark side effects is increased appetite and weight gain. Prednisone can stimulate appetite, leading individuals to consume more calories, which in turn can result in weight gain. Additionally, the medication can cause changes in metabolism and fat distribution, contributing to obesity, particularly in the abdominal area.

Fluid retention is also a recognized side effect of prolonged use of prednisone. This can lead to swelling in various parts of the body and contribute to increased blood pressure.

On the other hand, loss of hair on legs and knees is not a typical side effect associated with prednisone use. Hyperactivity and insomnia can occur with some medications, but they are not common with prednisone. Therefore, the side effects most prominently linked to long-term prednisone use include increased appetite, weight gain, and fluid retention, making these options more relevant in the context of the question.