Which common side effect is associated with opioid medications?

Opioid medications are well-known for causing constipation as a common side effect. This occurs because opioids bind to specific receptors in the gastrointestinal (GI) tract, which diminishes the motility of the intestines and increases the absorption of fluids from the intestinal contents, leading to harder stools that can be difficult to pass. This is a significant issue for many patients on long-term opioid therapy, prompting healthcare providers to often recommend laxatives or stool softeners as preventative measures.

The mechanism behind opioid-induced constipation highlights the importance of monitoring bowel habits in patients prescribed these medications. Other side effects of opioids may include sedation, nausea, and respiratory depression, but constipation remains particularly prevalent and notable because it can lead to discomfort and further complications if not addressed appropriately.