Which of the following medications is contraindicated with Prozac?

Prozac, known generically as fluoxetine, is a selective serotonin reuptake inhibitor (SSRI) commonly used to treat depression and anxiety disorders. When considering potential contraindications, particularly with anticoagulants like warfarin, it is important to understand the interactions that can arise.

The combination of Prozac and warfarin can increase the risk of bleeding. This occurs because fluoxetine can affect the metabolism of warfarin, leading to an increase in warfarin's anticoagulant effect. Therefore, careful monitoring of INR levels (international normalized ratio) is crucial when these two drugs are administered together. Adjustments to the warfarin dosage may be necessary to maintain therapeutic levels without increasing the risk of bleeding complications.

While aspirin, ibuprofen, and acetaminophen may have their own interactions and considerations, they do not carry the same level of contraindication when taken with Prozac as warfarin does. Aspirin and ibuprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs) and can increase bleeding risk on their own, especially when combined with other anticoagulants, but they do not specifically have a contraindication with Prozac as warfarin does. Acetaminophen generally has a safer profile